Heparin-induced thrombocytopenia (HIT) is a life and limb-threatening complication of
heparin exposure. Here, we review the pathogenesis, incidence, diagnosis, and …

Heparin-induced thrombocytopenia is a profoundly dangerous, potentially lethal,
immunologically mediated adverse drug reaction to unfractionated heparin or, less …

Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …

Background Thrombocytopenia and thrombosis are prominent in coronavirus disease 2019
(COVID‐19), particularly among critically ill patients; however, the mechanism is unclear …

Direct oral anticoagulants (DOACs) are attractive options for treatment of heparin-induced
thrombocytopenia (HIT). We report our continuing experience in Hamilton, ON, Canada …

Heparin‐induced thrombocytopenia (HIT) is a clinical‐pathological disorder; thus, laboratory
testing for the pathogenic platelet‐activating antiplatelet factor 4 (PF 4)/heparin antibodies is …

Coronavirus disease 2019 (COVID-19) is a highly prothrombotic viral infection that primarily
manifests as an acute respiratory syndrome. However, critically ill COVID-19 patients will …

Despite more than a half century of “safe” cardiopulmonary bypass (CPB), the evidence
base surrounding the conduct of anticoagulation therapy for CPB has not been organized …

Platelets are small, anucleate circulating cells that possess a dynamic repertoire of functions
spanning the hemostatic, inflammatory, and immune continuum. Once thought to be merely …

Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4/CXCL4) and
polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A …