Using optical tweezers, we have been able to study the interactions of small molecules and
prospective cancer drugs with DNA. One type of these molecules, known as threading …

The integrity of our DNA is constantly under threat from many internal and external factors. If
the cell cannot properly protect the integrity of DNA, errors (lesions) in DNA may form which …

Mitoxantrone is a chemotherapy drug that treats a variety of cancers by inhibiting cancer cell
replication through intercalation with DNA. Intercalation is the process by which certain small …

DNA pulling experiments in parallel. The technique is also relatively inexpensive and
straightforward to use, making it a suitable tool for undergraduate research. A benchtop …

Netropsin is an antibiotic that binds in the minor grooves of DNA, which also exhibits
anticancer properties. There have been many previous studies that explored the binding of …