Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

No disease modifying drugs have been approved for Alzheimer's disease despite recent
major investments by industry and governments throughout the world. The burden of …

Excess iron deposition in the brain often causes oxidative stress-related damage and
necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one …

Background Excessive iron contributes to oxidative stress after central nervous system
injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory …

The transition metal characteristics of iron allow it to play a fundamental role in several
essential aspects of human life such as the transport of oxygen through hemoglobin or the …

The present review reports a list of approximately 800 compounds which have been used,
tested or proposed for Parkinson's disease (PD) therapy in the year range 2014–2019 …

Accumulating evidence suggests that an abnormal accumulation of iron in the substantia
nigra (SN) is one of the defining characteristics of Parkinson's disease (PD). Accordingly, the …

Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often
found in damaged brain areas of Parkinson's disease. We propose that a causal link exists …

Iron accumulation is a recurring pathological phenomenon in many neurological diseases
including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and …

Background: There is a growing body of evidence in animal and cell based models of
Parkinson's disease (PD) to suggest that overexpression and/or abnormal accumulation and …