The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

Myocarditis (MC) is defined as an immunological inflammatory reaction with various
etiologies, clinical presentations and prognoses within the myocardium. Currently …

Chronic kidney disease (CKD) is a stealthy disease, and its development is linked to
mechanisms including inflammation and oxidative stress. Catalpol (CAT), an iridoid …

Background and purpose Chronic kidney disease (CKD), characterized by renal fibrosis, is a
global refractory disease with few effective therapeutic strategies. It has been reported that …

Aims Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular
events and exhibit myocardial changes including left ventricular (LV) hypertrophy and …

Hypertension is a risk factor for vascular injury and thrombotic complications, and smoking
tobacco is a risk factor for the development and exacerbation of hypertension. The influence …

Reactive oxygen species (ROS) are molecules deriving from the incomplete reduction of
molecular oxygen in the cell. They can be free radicals, atoms, and molecules with an …

Aims Chronic kidney disease (CKD) produces multiple repercussions in the gastrointestinal
tract (GIT), such as alterations in motility, gut microbiota, intestinal permeability, and …

Transmembrane proteins (TMEMs) are embedded in cell membranes and often have poorly
understood functions. Our RNAseq analysis identified 89 tmem genes in zebrafish …

Background Although thrombosis events are the leading complication of uremia, their
mechanism is largely unknown. The interaction between endothelial cells (ECs) and red …