Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

Chemotherapy remains the mainstay of treatment in the majority of solid and haematological
malignancies. Resistance to cytotoxic chemotherapy is a major clinical problem and …

Purpose Multiple-gene sequencing is entering practice, but its clinical value is unknown. We
evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk …

Summary Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid
tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the …

Gene panels for hereditary breast and ovarian cancer risk assessment are gaining
acceptance, even though the clinical utility of these panels is not yet fully defined. Technical …

The tumor microenvironment plays a key role in tumor development and progression.
Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which …

The MET proto-oncogene was first identified in osteosarcoma cells exposed to carcinogens.
Although expressed in many normal cells, MET is overexpressed in many human cancers …

Since the initial discovery of missense MET mutations in hereditary papillary renal
carcinoma (HPRC), activating MET mutations have been identified in a diverse range of …

Simple Summary The MET gene encodes a receptor critical for cell growth and repair. It
plays diverse roles in processes like organ development, wound healing, and blood vessel …

Hereditary syndromes causing colorectal cancer include both polyposis and non-polyposis
syndromes. Overlapping phenotypes between the syndromes have been recognized and …