Abstract Seizures in some 30% to 40% of patients with epilepsy fail to respond to
antiepileptic drugs or other treatments. While much has been made of the risks of new drug …

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

Recent years have witnessed a paradigm shift in the study and conceptualization of
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …

Is thought possible without language? Individuals with global aphasia, who have almost no
ability to understand or produce language, provide a powerful opportunity to find out …

Intractable focal epilepsy is a devastating disorder with profound effects on cognition and
quality of life. Epilepsy surgery can lead to seizure freedom in patients with focal epilepsy; …

Abstract Objective Ultra‐high‐field 7‐Tesla (7T) magnetic resonance imaging (MRI) offers
increased signal‐to‐noise and contrast‐to‐noise ratios, which may improve visualization of …

We review the applications and results of voxel‐based morphometry (VBM) studies that
have reported brain changes associated with temporal lobe epilepsy (TLE). A PubMed …

Objective: It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is
associated with cumulative brain damage, with no expert consensus and no quantitative …

Objective We evaluated whether deep learning applied to whole‐brain presurgical structural
connectomes could be used to predict postoperative seizure outcome more accurately than …

Impaired consciousness requires altered cortical function. This can occur either directly from
disorders that impair widespread bilateral regions of the cortex or indirectly through effects …