CLC chloride channels and transporters: structure, function, physiology, and disease

TJ Jentsch, M Pusch - Physiological reviews, 2018 - journals.physiology.org
CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

MS Van der Knaap, M Bugiani - Acta neuropathologica, 2017 - Springer
Leukodystrophies are genetically determined disorders characterized by the selective
involvement of the central nervous system white matter. Onset may be at any age, from …

[HTML][HTML] HepaCAM controls astrocyte self-organization and coupling

KT Baldwin, CX Tan, ST Strader, C Jiang, JT Savage… - Neuron, 2021 - cell.com
Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic
development and function. This process is regulated by transcellular interactions between …

Astrocytes in the regulation of cerebrovascular functions

M Cohen‐Salmon, L Slaoui, N Mazaré, A Gilbert… - Glia, 2021 - Wiley Online Library
Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

Heterogeneity of white matter astrocytes in the human brain

M Bugiani, BC Plug, JHK Man, M Breur… - Acta …, 2022 - Springer
Astrocytes regulate central nervous system development, maintain its homeostasis and
orchestrate repair upon injury. Emerging evidence support functional specialization of …

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

TJ Jentsch - The Journal of physiology, 2015 - Wiley Online Library
After providing a personal description of the convoluted path leading 25 years ago to the
molecular identification of the Torpedo Cl− channel ClC‐0 and the discovery of the CLC …

Metachromatic leukodystrophy and transplantation: Remyelination, no cross‐correction

NI Wolf, M Breur, B Plug, S Beerepoot… - Annals of clinical …, 2020 - Wiley Online Library
Objective In metachromatic leukodystrophy, a lysosomal storage disorder due to decreased
arylsulfatase A activity, hematopoietic stem cell transplantation may stop brain …

Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema

EMJ Passchier, S Kerst, E Brouwers, EMC Hamilton… - Brain, 2023 - academic.oup.com
Brain oedema is a life-threatening complication of various neurological conditions.
Understanding molecular mechanisms of brain volume regulation is critical for therapy …

Mlc1-Expressing Perivascular Astrocytes Promote Blood–Brain Barrier Integrity

JE Morales, A De, AA Miller, Z Chen… - Journal of …, 2022 - Soc Neuroscience
In the mammalian brain, perivascular astrocytes (PAs) closely juxtapose blood vessels and
are postulated to have important roles in the control of vascular physiology, including …

Astrocyte–oligodendrocyte–microglia crosstalk in astrocytopathies

DM de Waard, M Bugiani - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Defective astrocyte function due to a genetic mutation can have major consequences for
microglia and oligodendrocyte physiology, which in turn affects the white matter integrity of …