X-ray phase-contrast imaging: from pre-clinical applications towards clinics

A Bravin, P Coan, P Suortti - Physics in Medicine & Biology, 2012 - iopscience.iop.org
Phase-contrast x-ray imaging (PCI) is an innovative method that is sensitive to the refraction
of the x-rays in matter. PCI is particularly adapted to visualize weakly absorbing details like …

[HTML][HTML] Imaging drug delivery to the lungs: Methods and applications in oncology

F Man, J Tang, M Swedrowska, B Forbes… - Advanced Drug Delivery …, 2023 - Elsevier
Direct delivery to the lung via inhalation is arguably one of the most logical approaches to
treat lung cancer using drugs. However, despite significant efforts and investment in this …

X-ray phase imaging with a paper analyzer

KS Morgan, DM Paganin, KKW Siu - Applied Physics Letters, 2012 - pubs.aip.org
We present a simple x-ray phase imaging method that utilizes the sample-induced distortion
of a high contrast random intensity pattern to quantitatively retrieve the two-dimensional …

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

S Schleede, FG Meinel, M Bech… - Proceedings of the …, 2012 - National Acad Sciences
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change
in X-ray attenuation is not detectable with absorption-based radiography. To monitor the …

Pulmonary emphysema diagnosis with a preclinical small-animal x-ray dark-field scatter-contrast scanner

A Yaroshenko, FG Meinel, M Bech, A Tapfer… - Radiology, 2013 - pubs.rsna.org
Purpose To test the hypothesis that the joint distribution of x-ray transmission and dark-field
signals obtained with a compact cone-beam preclinical scanner with a polychromatic source …

A quality optimization approach to image Achilles tendon microstructure by phase-contrast enhanced synchrotron micro-tomography

M Pierantoni, I Silva Barreto, M Hammerman… - Scientific reports, 2021 - nature.com
Achilles tendons are mechanosensitive, and their complex hierarchical structure is in part
the result of the mechanical stimulation conveyed by the muscles. To fully understand how …

3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography

M Eckermann, J Frohn, M Reichardt, M Osterhoff… - Elife, 2020 - elifesciences.org
We present a three-dimensional (3D) approach for virtual histology and histopathology
based on multi-scale phase contrast x-ray tomography, and use this to investigate the …

Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid

KS Morgan, DM Paganin, KKW Siu - Optics express, 2011 - opg.optica.org
A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal
in vivo observations, is described and shown experimentally both for a known static sample …

Cartilage tissue engineering approaches need to assess fibrocartilage when hydrogel constructs are mechanically loaded

H Alizadeh Sardroud, T Wanlin, X Chen… - … in Bioengineering and …, 2022 - frontiersin.org
Chondrocytes that are impregnated within hydrogel constructs sense applied mechanical
force and can respond by expressing collagens, which are deposited into the extracellular …

Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography

J Reichmann, SE Verleden, M Kühnel… - Physics in Medicine …, 2023 - iopscience.iop.org
Objectives. As the central organ of the respiratory system, the human lung is responsible for
supplying oxygen to the blood, which reaches the erythrocytes by diffusion through the …