Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives
Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …
diseases. Although many intracellular signaling pathways influence cardiac physiology and …
Novel mechanisms of endothelial mechanotransduction
Atherosclerosis is a focal disease that develops preferentially where nonlaminar, disturbed
blood flow occurs, such as branches, bifurcations, and curvatures of large arteries …
blood flow occurs, such as branches, bifurcations, and curvatures of large arteries …
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis
Background—Diabetes mellitus is a major risk factor for cardiovascular mortality by
increasing endothelial cell (EC) dysfunction and subsequently accelerating atherosclerosis …
increasing endothelial cell (EC) dysfunction and subsequently accelerating atherosclerosis …
An ERK5-NRF2 axis mediates senescence-associated stemness and atherosclerosis
Background: ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …
Statin-regulated phagocytosis and efferocytosis in physiological and pathological conditions
Efferocytosis (clearance of apoptotic cells by phagocytosis without inducing inflammation
and autoimmunity) is an important mechanism in the resolution of inflammatory processes …
and autoimmunity) is an important mechanism in the resolution of inflammatory processes …
Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
W Liu, A Ruiz-Velasco, S Wang, S Khan, M Zi… - Nature …, 2017 - nature.com
The prevalence of cardiomyopathy from metabolic stress has increased dramatically;
however, its molecular mechanisms remain elusive. Here, we show that extracellular signal …
however, its molecular mechanisms remain elusive. Here, we show that extracellular signal …
Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function
Disturbed blood flow (d-flow) causes endothelial cell (EC) dysfunction, leading to
atherosclerotic plaque formation. We have previously shown that d-flow increases …
atherosclerotic plaque formation. We have previously shown that d-flow increases …
Proteasome dysfunction in cardiomyopathies
JE Gilda, AV Gomes - The Journal of physiology, 2017 - Wiley Online Library
The ubiquitin–proteasome system (UPS) plays a critical role in removing unwanted
intracellular proteins and is involved in protein quality control, signalling and cell death …
intracellular proteins and is involved in protein quality control, signalling and cell death …
Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient
and growth factor signaling and is strongly implicated in cancer. But mTOR is not an …
and growth factor signaling and is strongly implicated in cancer. But mTOR is not an …
The E3 ligase CHIP: insights into its structure and regulation
The carboxy‐terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase
containing three tandem repeats of tetratricopeptide (TPR) motifs and a C‐terminal U‐box …
containing three tandem repeats of tetratricopeptide (TPR) motifs and a C‐terminal U‐box …