Artificial intelligence in drug development

K Zhang, X Yang, Y Wang, Y Yu, N Huang, G Li, X Li… - Nature Medicine, 2025 - nature.com
Drug development is a complex and time-consuming endeavor that traditionally relies on the
experience of drug developers and trial-and-error experimentation. The advent of artificial …

[HTML][HTML] Artificial intelligence in lung cancer: current applications, future perspectives, and challenges

D Huang, Z Li, T Jiang, C Yang, N Li - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Artificial intelligence (AI) has significantly impacted various fields, including oncology. This
comprehensive review examines the current applications and future prospects of AI in lung …

Functionalized Multichannel Fluorescence-Encoded Nanosystem on Erythrocyte-Coated Nanoparticles for Precise Cancer Subtype Discrimination

X Zhu, J Chen, J Liao, M Wang, Y Long, M Liu… - Nano Letters, 2024 - ACS Publications
Rapid and precise cancer subtype discrimination is essential for personalized oncology.
Conventional diagnostic methods often lack sufficient accuracy and speed. Here, we …

[HTML][HTML] Self-supervised learning reveals clinically relevant histomorphological patterns for therapeutic strategies in colon cancer

B Liu, M Polack, N Coudray, AC Quiros… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Self-supervised learning (SSL) automates the extraction and interpretation of histopathology
features on unannotated hematoxylin-and-eosin-stained whole-slide images (WSIs). We …

Quantitative and Morphology-Based Deep Convolutional Neural Network Approaches for Osteosarcoma Survival Prediction in the Neoadjuvant and Metastatic …

N Coudray, MA Occidental, JG Mantilla… - Clinical Cancer …, 2025 - aacrjournals.org
Purpose: Necrosis quantification in the neoadjuvant setting using pathology slide review is
the most important validated prognostic marker in conventional osteosarcoma. Herein, we …

Integrated multicenter deep learning system for prognostic prediction in bladder cancer

Q He, B Xiao, Y Tan, J Wang, H Tan, C Peng… - NPJ Precision …, 2024 - nature.com
Precise survival risk stratification is crucial for personalized therapy in bladder cancer (BCa).
This study developed and validated an end-to-end deep learning system using histological …

Deep learning model for automated diagnosis of moyamoya disease based on magnetic resonance angiography

M Lu, Y Zheng, S Liu, X Zhang, J Lv, Y Liu, B Li… - …, 2024 - thelancet.com
Background This study explores the potential of the deep learning-based convolutional
neural network (CNN) to automatically recognize MMD using MRA images from …

Implementing Trust in Non-Small Cell Lung Cancer Diagnosis with a Conformalized Uncertainty-Aware AI Framework in Whole-Slide Images

X Zhang, T Wang, C Yan, F Najdawi, K Zhou, Y Ma… - medRxiv, 2024 - medrxiv.org
Ensuring trustworthiness is fundamental to the development of artificial intelligence (AI) that
is considered societally responsible, particularly in cancer diagnostics, where a …

Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopy

Z Zhang, Y Wu, S Spies, P Wesseling, ML Groot - 2024 - researchsquare.com
Histopathological assessment is the corner stone for tumor diagnosis in the clinic, but it is in
its optimal form (using paraffin-embedded sections) not readily available during surgery. The …

A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images

F Seyedshahi, K Rakovic, N Poulain, AC Quiros… - bioRxiv, 2024 - biorxiv.org
Mesothelioma is a highly lethal and poorly biologically understood disease which presents
diagnostic challenges due to its morphological complexity. This study uses self-supervised …