Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

[HTML][HTML] Cellular and molecular mechanisms of mitochondrial function

LD Osellame, TS Blacker, MR Duchen - Best practice & research Clinical …, 2012 - Elsevier
Mitochondria are membrane bound organelles present in almost all eukaryotic cells.
Responsible for orchestrating cellular energy production, they are central to the …

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

H Lee, TJ Lee, CA Galloway, W Zhi, W Xiao… - Nature …, 2023 - nature.com
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …

Mitochondrial aging and age‐related dysfunction of mitochondria

DA Chistiakov, IA Sobenin, VV Revin… - BioMed research …, 2014 - Wiley Online Library
Age‐related changes in mitochondria are associated with decline in mitochondrial function.
With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to …

[HTML][HTML] Bioenergetic role of mitochondrial fusion and fission

B Westermann - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012 - Elsevier
Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the
morphology of the mitochondrial compartment to the metabolic needs of the cell …

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

M Morigi, L Perico, C Rota, L Longaretti… - The Journal of …, 2015 - Am Soc Clin Investig
Acute kidney injury (AKI) is a public health concern with an annual mortality rate that
exceeds those of breast and prostate cancer, heart failure, and diabetes combined …

Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential

E Fragouli, K Spath, S Alfarawati, F Kaper, A Craig… - PLoS …, 2015 - journals.plos.org
Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial …

M Manczak, PH Reddy - Human molecular genetics, 2012 - academic.oup.com
We recently reported increased mitochondrial fission and decreased fusion, increased
amyloid beta (Aβ) interaction with the mitochondrial fission protein Drp1, increased …

Oocyte mitochondrial function and reproduction

E Babayev, E Seli - Current Opinion in Obstetrics and Gynecology, 2015 - journals.lww.com
Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

S Di Meo, S Iossa, P Venditti - Journal of Endocrinology, 2017 - joe.bioscientifica.com
Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …