Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
Chitosan–Biotin-Conjugated PH-Responsive Ru (II) Glucose Nanogel: A Dual Pathway of Targeting Cancer Cells and Self-Drug Delivery
The current study paves the way for improved chemotherapy by creating pH-responsive
nanogels (NGs)(GC1 and GC2) loaded with synthetic ruthenium (II) arene complexes to …
nanogels (NGs)(GC1 and GC2) loaded with synthetic ruthenium (II) arene complexes to …
The immunomodulatory effects of vitamins in cancer
Nutrition may affect animal health due to the strong link between them. Also, diets improve
the healing process in various disease states. Cancer is a disease, where the harmful …
the healing process in various disease states. Cancer is a disease, where the harmful …
Pyrene-based fluorescent Ru (ii)-arene complexes for significant biological applications: catalytic potential, DNA/protein binding, two photon cell imaging and in vitro …
Ruthenium complexes are being studied extensively as anticancer drugs following the
inclusion of NAMI-A and KP1019 in phase II clinical trials for the treatment of metastatic …
inclusion of NAMI-A and KP1019 in phase II clinical trials for the treatment of metastatic …
Spectroscopic study and molecular simulation: Bovine serum albumin binding with anticancer Pt complex of amyl dithiocarbamate ligand
Until now, many methods have been proposed to treat cancer, such as radiation therapy and
drug therapy, but none of them have caused a complete cure for cancer. Heavy metal …
drug therapy, but none of them have caused a complete cure for cancer. Heavy metal …
A Novel Ibuprofen Derivative and Its Complexes: Physicochemical Characterization, DFT Modeling, Docking, In Vitro Anti-Inflammatory Studies, and DNA Interaction
A novel derivative of ibuprofen and salicylaldehyde N′-(4-hydroxybenzylidene)-2-(4-
isobutylphenyl) propane hydrazide (HL) was synthesized, followed by its complexation with …
isobutylphenyl) propane hydrazide (HL) was synthesized, followed by its complexation with …
Nanoconstructs for theranostic application in cancer: Challenges and strategies to enhance the delivery
S Mishra, T Bhatt, H Kumar, R Jain, S Shilpi… - Frontiers in …, 2023 - frontiersin.org
Nanoconstructs are made up of nanoparticles and ligands, which can deliver the loaded
cargo at the desired site of action. Various nanoparticulate platforms have been utilized for …
cargo at the desired site of action. Various nanoparticulate platforms have been utilized for …
A new chitosan-based thermosensitive nanoplatform for combined photothermal and chemotherapy
Y Zhang, GR Williams, J Lou, W Li, C Bai… - International Journal of …, 2022 - Elsevier
Targeting the delivery of anti-cancer drugs to a tumor site is essential for effective treatment
and to ensure minimal damage to healthy cells and tissues. In this work, a chitosan-based …
and to ensure minimal damage to healthy cells and tissues. In this work, a chitosan-based …
Studies on anticancer properties with varying co-ligands in a Ru (II) arene benzimidazole system
S Nayek, S Singh, A Sonawane, I Grabchev… - Dalton …, 2023 - pubs.rsc.org
Recently in the field of chemotherapeutics, to combat the side effects of cisplatin, ruthenium
complexes have been investigated extensively. In this work, a bidentate benzimidazole …
complexes have been investigated extensively. In this work, a bidentate benzimidazole …
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn (ii), Co (ii) and Ni (ii) complexes …
K Sakthikumar, BK Isamura, RWM Krause - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
A novel class of bioactive complexes (1–3)[MII (L) 2 (bpy)], where, L= 2-(4-
morpholinobenzylideneamino) phenol, bpy= 2, 2′-bipyridine, MII= Mn (1), Co (2) or Ni (3) …
morpholinobenzylideneamino) phenol, bpy= 2, 2′-bipyridine, MII= Mn (1), Co (2) or Ni (3) …