Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?

G Kour, R Choudhary, S Anjum, A Bhagat… - Biochemical …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the
use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent …

The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis

M Wang, YH Xiang, M Liu, S Jiang, J Guo… - Frontiers in …, 2024 - frontiersin.org
Sacha Inchi (Plukenetia volubilis L)(SI) is a traditional natural medicine from tropical
rainforests of Amazon region in South America. As a raw material for edible oil, it has various …

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund's adjuvant-induced rheumatoid arthritis model

C Zhang, W Zhang, R Shi, B Tang, S Xie - Pharmaceutical biology, 2019 - Taylor & Francis
Abstract Context: Adlay seed [Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf
(Poaceae)] is a Traditional Chinese Medicine, which has been investigated to treat …

Cassia absus-mediated upregulation of IL-4, IL-10 and downregulation of IL-1β, IL-6, TNF- α, NF-κB, IFN-γ in CFA-induced arthritis model

B Gul, R Anwar, M Saleem, A Noor, MI Ullah - Inflammopharmacology, 2023 - Springer
Traditional use of Cassia absus as an anti-inflammatory in conjunctivitis and bronchitis is
well reported. Owing to its anti-inflammatory potential, the current study appraised in vivo …

Integrating network pharmacology with molecular docking to unravel the active compounds and potential mechanism of simiao pill treating rheumatoid arthritis

M Tang, X Xie, P Yi, J Kang, J Liao… - Evidence‐Based …, 2020 - Wiley Online Library
Objective. To explore the main components and unravel the potential mechanism of simiao
pill (SM) on rheumatoid arthritis (RA) based on network pharmacological analysis and …

Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid …

S Samarpita, R Ganesan, M Rasool - Toxicology and applied …, 2020 - Elsevier
The hyperplastic phenotype of fibroblast-like synoviocytes (FLSs) plays an important role for
synovitis, chronic inflammation and joint destruction in rheumatoid arthritis (RA). Interleukin …

Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts

B Gul, R Anwar, M Saleem, M Ahmad, MI Ullah… - …, 2023 - Springer
Solanum nigrum L. is a popular traditional medicine for various inflammatory conditions
including rheumatism and joint pain. The current study aimed to evaluate the anti-arthritic …

Enhancement and repair of degenerative intervertebral disc in rats using platelet-rich plasma/ferulic acid hydrogel

Q Chai, B Zhang, Y Da, W Wang, Y Gao, M Yao… - Cartilage, 2023 - journals.sagepub.com
Background Intervertebral degenerative disc (IDD) disease is one of the most common
clinical conditions causing low back pain. The main objective of this study was to investigate …

Anti-inflammation is an important way that Qingre-Huazhuo-Jiangsuan recipe treats acute gouty arthritis

Y Wang, Y Xu, J Tan, J Ye, W Cui, J Hou… - Frontiers in …, 2023 - frontiersin.org
Background: Acute gouty arthritis (AGA) significantly impairs patients' quality of life.
Currently, existing therapeutic agents exhibit definite efficacy but also lead to serious …

Tuning Ferulic Acid Solubility in Choline-Chloride-and Betaine-Based Deep Eutectic Solvents: Experimental Determination and Machine Learning Modeling

T Jeliński, M Przybyłek, R Różalski, K Romanek… - …, 2024 - pmc.ncbi.nlm.nih.gov
Deep eutectic solvents (DES) represent a promising class of green solvents, offering
particular utility in the extraction and development of new formulations of natural compounds …