Photodynamic therapy for basal cell carcinoma: the clinical context for future research priorities

NJ Collier, LE Rhodes - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell
carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in …

Molecular effectors of photodynamic therapy-mediated resistance to cancer cells

EC Aniogo, BP George, H Abrahamse - International journal of molecular …, 2021 - mdpi.com
Photodynamic therapy (PDT) is currently enjoying considerable attention as the subject of
experimental research to treat resistant cancers. The preferential accumulation of a non …

Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling

NM Carigga Gutierrez, N Pujol-Solé, Q Arifi… - Cancer and Metastasis …, 2022 - Springer
The dense cancer microenvironment is a significant barrier that limits the penetration of
anticancer agents, thereby restraining the efficacy of molecular and nanoscale cancer …

[HTML][HTML] Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy

M Mascaraque-Checa, M Gallego-Rentero… - Molecular …, 2022 - Elsevier
Objective Cancer metabolic reprogramming promotes resistance to therapies. In this study,
we addressed the role of the Warburg effect in the resistance to photodynamic therapy (PDT) …

PTCH1 gene variants rs357564, rs2236405, rs2297086 and rs41313327, mRNA and tissue expression in basal cell carcinoma patients from Western Mexico

M Zambrano‐Román… - Journal of Clinical …, 2024 - Wiley Online Library
Background Basal cell carcinoma (BCC) represents about 80% of all cases of skin cancer.
The PTCH1 is a transmembrane protein of the Sonic Hedgehog signaling pathway that …

Comparative response to PDT with methyl-aminolevulinate and temoporfin in cutaneous and oral squamous cell carcinoma cells

J Nicolás-Morala, M Alonso-Juarranz, A Barahona… - Scientific Reports, 2024 - nature.com
Abstract Cutaneous and Head and Neck squamous cell carcinoma (CSCC, HNSCC) are
among the most prevalent cancers. Both types of cancer can be treated with photodynamic …

Epigallocatechin gallate enhances MAL-PDT cytotoxic effect on PDT-resistant skin cancer squamous cells

D León, K Buchegger, R Silva, I Riquelme… - International journal of …, 2020 - mdpi.com
Photodynamic therapy (PDT) has been used to treat certain types of non-melanoma skin
cancer with promising results. However, some skin lesions have not fully responded to this …

Metformin as an adjuvant to photodynamic therapy in resistant basal cell carcinoma cells

M Mascaraque, P Delgado-Wicke, C Nuevo-Tapioles… - Cancers, 2020 - mdpi.com
Photodynamic Therapy (PDT) with methyl-aminolevulinate (MAL-PDT) is being used for the
treatment of Basal Cell Carcinoma (BCC), although resistant cells may appear. Normal …

The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 …

J Nicolás-Morala… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Squamous Cell Carcinoma (SCC) is a subtype of Non-Melanoma Skin Cancer, the most
common group of malignancies worldwide. Photodynamic therapy (PDT) is a non-invasive …

Antioxidant Enzymes in Cancer Cells: Their Role in Photodynamic Therapy Resistance and Potential as Targets for Improved Treatment Outcomes

W Udomsak, M Kucinska, J Pospieszna… - International Journal of …, 2024 - mdpi.com
Photodynamic therapy (PDT) is a selective tumor treatment that consists of a photosensitive
compound—a photosensitizer (PS), oxygen, and visible light. Although each component has …