Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Trypanosoma cruzi, the causative agent of Chagas′ disease, which affects a large number
of individuals in Central and South America, is transmitted to vertebrate hosts by blood …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on
a series of events involving interactions of diverse parasite molecules with host components …

Streptococcal pyrogenic exotoxin B (SPE B), a conserved extracellular cysteine protease
expressed by the human pathogenic bacterium Streptococcus pyogenes, was purified and …

The complete sequence of the gene encoding the major cysteine protease from
Trypanosoma cruzi is reported. The amino acid sequence predicted from the gene …

Streptococcus pyogenes secretes an extracellular cysteine protease that cleaves human
interleukin 1β precursor to form biologically active IL 1β, a major cytokine mediating …

The parasitic protozoan Trypanosoma cruzi employs multiple molecular strategies to invade
a broad range of nonphagocytic cells. Here we demonstrate that the invasion of human …

Peptidyl diazomethane (PDAM) derivatives, a class of irreversible inhibitors for cysteine
proteinase, were screened for the ability to impair Trypanosoma cruzi invasion and …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains
cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among …