The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

[HTML][HTML] Engineering exosomes for targeted drug delivery

Y Liang, L Duan, J Lu, J Xia - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation
of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be …

Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications

Y Zhang, J Bi, J Huang, Y Tang, S Du… - International journal of …, 2020 - Taylor & Francis
Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic
acids, proteins, lipids and other bioactive substances to play a role in the body's …

Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

Exosome-based smart drug delivery tool for cancer theranostics

R Kar, R Dhar, S Mukherjee, S Nag… - ACS biomaterials …, 2023 - ACS Publications
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles
derived from the plasma membrane. The main activity of exosomes is cellular …

Engineering macrophages for cancer immunotherapy and drug delivery

Y Xia, L Rao, H Yao, Z Wang, P Ning… - Advanced …, 2020 - Wiley Online Library
Macrophages play an important role in cancer development and metastasis.
Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 …

Exosomes, a new star for targeted delivery

H Chen, L Wang, X Zeng, H Schwarz… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

The evolving translational potential of small extracellular vesicles in cancer

A Möller, RJ Lobb - Nature Reviews Cancer, 2020 - nature.com
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …