[HTML][HTML] Biomedical applications of engineered heparin-based materials

EN Zare, D Khorsandi, A Zarepour, H Yilmaz… - Bioactive Materials, 2024 - Elsevier
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …

Glycosaminoglycans: from vascular physiology to tissue engineering applications

AJ Lepedda, G Nieddu, M Formato, MB Baker… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular diseases represent the number one cause of death globally, with
atherosclerosis a major contributor. Despite the clinical need for functional arterial …

High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity

Z Fang, J Chen, Y Zhu, G Hu, H Xin, K Guo, Q Li… - Nature …, 2021 - nature.com
Peptides are widely used for surface modification to develop improved implants, such as cell
adhesion RGD peptide and antimicrobial peptide (AMP). However, it is a daunting challenge …

In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application

BO Awonusi, J Li, H Li, Z Wang, K Yang… - Regenerative …, 2022 - academic.oup.com
Ureteral stents are commonly utilized as a medical device to aid the flow of urine. However,
biofilm formation and encrustation complications have been clinical problems. To overcome …

[HTML][HTML] Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch

JW Tierney, BC Evans, J Cheung-Flynn, B Wang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to
intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) …

Blood biocompatibility enhancement of biomaterials by heparin immobilization: a review

H Patel - Blood Coagulation & Fibrinolysis, 2021 - journals.lww.com
Blood contacting materials are concerned with biocompatibility including thrombus
formation, decrease blood coagulation time, hematology, activation of complement system …

In vivo study on heparin/poly-l-lysine-copper coating for surface functionalization of ureteral stent

BO Awonusi, J Li, H Li, Z Wang, J Hu… - Regenerative …, 2022 - academic.oup.com
Polyurethane (PU) ureteral stents are used in clinics to maintain the ureteral patency. Due to
biofilm formation and encrustation complications, long-term clinical usage has been limited …

Perivascular application of sirolimus multilayer nanofibrous mat for prevention of vascular stenosis: Preparation, In vitro characterization, and In vivo efficacy …

R Talimi, S Rabbani, F Mehryab, A Haeri - Journal of Drug Delivery Science …, 2022 - Elsevier
Graft stenosis, occurring after coronary artery bypass surgery (CABG), diminishes the
efficacy and long-term patency of vascular interventions. Multilayer nanofibers (NFs) are …

Rapid-Test Kit for Cardiac Troponin I: A Reliable Enzyme-Linked-Immuno-Substrate-Assay-Based Biosensor for Daily-Use Naked-Eye Detection and Pharmacokinetic …

YF Hsieh, KJ Lin - ACS Pharmacology & Translational Science, 2024 - ACS Publications
Myocardial infarction (MI) is a severe cardiovascular event that can lead to death. Cardiac
troponin I (cTnI) is an MI biomarker in the circulation system; however, methods for detecting …

Tissue engineering for mimics and modulations of immune functions

C Tao, DA Wang - Advanced Healthcare Materials, 2021 - Wiley Online Library
In the field of regenerative medicine, advances in tissue engineering have surpassed the
reconstruction of individual tissues or organs and begun to work towards engineering …