BACKGROUND Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in
their function leading to decreased insulin secretion or may arise from insulin resistance and …

Background—Secreted factors from epicardial adipose tissue (EAT) have been implicated in
the development of cardiomyocyte dysfunction. This study aimed to assess whether …

Background Several myokines are produced by cardiac muscle. We investigated changes in
myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in …

Type 2 diabetes mellitus (T2DM) is strongly associated with increased risk of myocardial
dysfunction and cardiovascular disease (CVD), two separate conditions which often co-exist …

Activin A is a key regulator of cardiac fibrosis. However, little is known about the
mechanisms by which it contributes to cardiac fibrosis. Our study explored the effects of …

Background Plasma follistatin is elevated in patients with low‐grade inflammation and
insulin resistance as observed with polycystic ovary syndrome. In the present study, we …

Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains
one of the cancers with the highest mortality rates. Activin A has been implicated in colon …

Abstract Type 1 diabetes (T1D) is associated with subfertility in men. We hypothesised that
this results from inhibitory effects of chronic hyperglycemia on testicular function and used …

Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent
manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion …

Recent studies have suggested that a low concentration of follicle‐stimulating hormone
(FSH) is associated with a higher prevalence of metabolic disturbances in postmenopausal …