Branching and converging pathways in fungal natural product biosynthesis

X Wei, WG Wang, Y Matsuda - Fungal Biology and Biotechnology, 2022 - Springer
In nature, organic molecules with great structural diversity and complexity are synthesized
by utilizing a relatively small number of starting materials. A synthetic strategy adopted by …

Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

S Fatima, AF Zahoor, SG Khan, SAR Naqvi… - RSC …, 2024 - pubs.rsc.org
Baeyer–Villiger oxidation is a well-known reaction utilized for the synthesis of lactones and
ester functionalities from ketones. Chiral lactones can be synthesized from chiral or racemic …

Discovery of the Biosynthetic Pathway of Beticolin 1 Reveals a Novel Non‐Heme Iron‐Dependent Oxygenase for Anthraquinone Ring Cleavage

X Hou, H Xu, Z Deng, Y Yan, Z Yuan… - Angewandte Chemie …, 2022 - Wiley Online Library
This study used light‐mediated comparative transcriptomics to identify the biosynthetic gene
cluster of beticolin 1 in Cercospora. It contains an anthraquinone moiety and an unusual …

Terricoxanthones A–E, unprecedented dihydropyran-containing dimeric xanthones from the endophytic fungus Neurospora terricola HDF-Br-2 associated with the …

HW Chen, XY Wu, ZY Zhao, ZQ Huang, XS Lei… - Phytochemistry, 2024 - Elsevier
An investigation on the secondary metabolites from a rice culture broth of the endophytic
fungus Neurospora terricola HDF-Br-2 derived from the vulnerable conifer Pseudotsuga …

Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para–Para Selective Phenol Coupling Dimerase

SW Yuan, SH Chen, H Guo, LT Chen, HJ Shen… - Organic …, 2022 - ACS Publications
Fungal cytochrome P450 enzymes have been shown to catalyze regio-and stereoselective
oxidative intermolecular phenol coupling. However, an enzyme capable of catalyzing …

Paecilins F–P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A

PP Wei, HL Ai, BB Shi, K Ye, X Lv, XY Pan… - Frontiers in …, 2022 - frontiersin.org
A total of eleven new dimeric chromanones, paecilins FP (2–12), were isolated from the
endophytic fungus Xylaria curta E10, along with four known analogs (1, 13–15). Their …

Discovery of a Fungal P450 with an Unusual Two-Step Mechanism for Constructing a Bicyclo [3.2. 2] nonane Skeleton

H Xu, Z Yuan, S Yang, Z Su, XD Hou… - Journal of the …, 2024 - ACS Publications
The successful biomimetic or chemoenzymatic synthesis of target natural products (NPs)
and their derivatives relies on enzyme discovery. Herein, we discover a fungal P450 BTG5 …

Cladoxanthones A and B, Xanthone-Derived Metabolites with a Spiro [cyclopentane-1, 2′-[3, 9a] ethanoxanthene]-2, 4′, 9′, 11′-tetraone Skeleton from a …

Y Zhang, P Fu, Y Zhang, Y Xu, C Zhang… - Journal of Natural …, 2022 - ACS Publications
Cladoxanthones A (1) and B (2), two xanthone-derived metabolites featuring a new spiro
[cyclopentane-1, 2′-[3, 9a] ethanoxanthene]-2, 4′, 9′, 11′(4a′ H)-tetraone skeleton …

Biosynthetic characterization, heterologous production, and genomics-guided discovery of GABA-containing fungal heptapeptides

X Wei, TK Chan, CTD Kong… - Journal of Natural …, 2023 - ACS Publications
The biosynthetic gene cluster of γ-aminobutyric acid (GABA)-containing fungal cyclic
heptapeptides unguisins A (1) and B (2) was identified in the fungus Aspergillus …

Biosynthetic pathways of dimeric natural products containing bisanthraquinone and related xanthones

Z Yuan, H Xu, Y Zhang, Y Rao - ChemBioChem, 2023 - Wiley Online Library
Many dimeric natural products containing bisanthraquinone and related xanthones with
diverse structures and versatile bioactivities have been isolated over the years. However …