Flavones: An important scaffold for medicinal chemistry

M Singh, M Kaur, O Silakari - European journal of medicinal chemistry, 2014 - Elsevier
Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …

Advances on nanoformulation approaches for delivering plant-derived antioxidants: a case of quercetin

S Rathod, S Arya, S Kanike, SA Shah… - International Journal of …, 2022 - Elsevier
Oxidative stress has been implicated in tumorigenic, cardiovascular, neuro-, and age-related
degenerative changes. Antioxidants minimize the oxidative damage through neutralization …

Synthesis, crystal structures, spectroscopic and nonlinear optical properties of chalcone derivatives: a combined experimental and theoretical study

MN Arshad, AAM Al-Dies, AM Asiri, M Khalid… - Journal of Molecular …, 2017 - Elsevier
A set of chalcone compounds were prepared by reacting p-bromoacetophenone with
various substituted aromatic aldehyde in ethanol using sodium ethoxide as base. The …

Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones

T Yatabe, X Jin, K Yamaguchi… - Angewandte Chemie …, 2015 - Wiley Online Library
Flavones are a class of natural products with diverse biological activities and have
frequently been synthesized by step‐by‐step procedures using stoichiometric amounts of …

In memory of Prof. Venkataraman: Recent advances in the synthetic methodologies of flavones

R Kshatriya, VP Jejurkar, S Saha - Tetrahedron, 2018 - Elsevier
Flavones are present in a variety of medicines and natural products and are important
structural motif due to their unique mode of physiological action. Hence the structural …

Cp* Ir (III) and Cp* Rh (III)-catalyzed annulation of salicylaldehydes with fluorinated vinyl tosylates

S Zhao, X Cai, Y Lu, J Hu, Z Xiong, J Jin, Y Li… - Chemical …, 2022 - pubs.rsc.org
A mild, selective and redox-neutral Cp* Ir (III)-and Cp* Rh (III)-catalyzed C–H
activation/annulation of salicylaldehydes with fluorovinyl tosylates is reported. The use of …

Unified approach to (thio) chromenones via one-pot friedel–crafts acylation/cyclization: distinctive mechanistic pathways of β-chlorovinyl ketones

HY Kim, E Song, K Oh - Organic letters, 2017 - ACS Publications
A facile synthetic method to chromenones and thiochromenones has been developed using
a one-pot Friedel–Crafts acylation of alkynes with suitably substituted benzoyl chlorides …

Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure–activity relationship and molecular modelling simulations

EU Mughal, A Sadiq, M Ayub, N Naeem… - Journal of …, 2021 - Taylor & Francis
In this protocol, a series of 3-benzyloxyflavone derivatives have been designed,
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …

Fluorine-containing chrysin derivatives: synthesis and biological activity

Y Zhu, X Yao, J Long, R Li, Y Liu… - Natural Product …, 2019 - journals.sagepub.com
Chrysin, a flavonoid, has played a great role in the fields of anticancer, antibacterial, and
antiviral drug discovery. A large number of chrysin derivatives have been synthesized …

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

CG Halpani, S Mishra - Tetrahedron Letters, 2020 - Elsevier
Ca (OTf) 2 in combination with NBu 4. BF 4 was established to function as an efficient
catalyst system for one-pot Claisen-Schmidt condensation under neat conditions …