Modeling and analysis of RNA‐seq data: a review from a statistical perspective

WV Li, JJ Li - Quantitative Biology, 2018 - Wiley Online Library
Background Since the invention of next‐generation RNA sequencing (RNA‐seq)
technologies, they have become a powerful tool to study the presence and quantity of RNA …

scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data

K Qian, S Fu, H Li, WV Li - Genome biology, 2022 - Springer
The increasing number of scRNA-seq data emphasizes the need for integrative analysis to
interpret similarities and differences between single-cell samples. Although different batch …

AIDE: annotation-assisted isoform discovery with high precision

WV Li, S Li, X Tong, L Deng, H Shi, JJ Li - Genome research, 2019 - genome.cshlp.org
Genome-wide accurate identification and quantification of full-length mRNA isoforms is
crucial for investigating transcriptional and posttranscriptional regulatory mechanisms of …

[HTML][HTML] 多条件多样本RNA-Seq 数据的剪切异构体表达水平估计

张礼, 马越, 吴东洋 - 智能系统学报, 2021 - html.rhhz.net
当处理多条件多样本RNA-Seq 测序数据时, 现有方法忽略了读段分布样本之间存在高度相似性
的特点. 本文提出了一个基于多条件多样本RNA-Seq 测序数据剪切异构体表达水平估计方法 …

[PDF][PDF] AIDE: annotation-assisted isoform discovery and abundance estimation from RNA-seq data

WV Li, S Li, X Tong, L Deng, H Shi, JJ Li - scholar.archive.org
Genome-wide accurate identification and quantification of full-length mRNA isoforms is
crucial for investigating transcriptional and post-transcriptional regulatory mechanisms of …

Developing Quantitative Models in Analyzing High-throughput Sequencing Data

YS Kim - 2021 - search.proquest.com
Diverse functional genomics assays have been developed and helped to investigate
complex gene regulations in various biological conditions. For example, RNA-seq has been …

Computational approaches for improving the accuracy and efficiency of RNA-seq analysis

H Sarkar - 2020 - search.proquest.com
The past decade has seen tremendous growth in the area of high throughput sequencing
technology, which simultaneously improved the biological resolution and subsequent …

[PDF][PDF] review from a statistical perspective

WV Li, JJ Li - qcb.ucla.edu
Background: Since the invention of next-generation RNA sequencing (RNA-seq)
technologies, they have become a powerful tool to study the presence and quantity of RNA …

[图书][B] The analysis of RNA-Seq experiments using approximate likelihood

DC Jones - 2020 - search.proquest.com
The analysis of mRNA transcript abundance with RNA-Seq is a central tool in molecular
biology research, but often analyses fail to account for the uncertainty in these estimates …

AIDE: annotation-assisted isoform discovery and abundance estimation with high precision

WV Li, S Li, X Tong, L Deng, H Shi, JJ Li - bioRxiv, 2018 - biorxiv.org
Genome-wide accurate identification and quantification of full-length mRNA isoforms is
crucial for investigating transcriptional and post-transcriptional regulatory mechanisms of …