Obsessive-compulsive disorder: puzzles and prospects

TW Robbins, MM Vaghi, P Banca - Neuron, 2019 - cell.com
Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

DL Pauls, A Abramovitch, SL Rauch… - Nature Reviews …, 2014 - nature.com
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Mechanisms of glutamate transport

RJ Vandenberg, RM Ryan - Physiological reviews, 2013 - journals.physiology.org
l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

The error-related negativity (ERN/Ne)

WJ Gehring, Y Liu, JM Orr, J Carp - Oxford handbook of event …, 2012 - books.google.com
We review two decades of research on the error-related negativity (ERN or Ne), a
component of the event-related brain potential that accompanies errors in speeded …

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

M Mattheisen, JF Samuels, Y Wang… - Molecular …, 2015 - nature.com
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …

Obsessive-compulsive disorder

JS Abramowitz, S Taylor, D McKay - The Lancet, 2009 - thelancet.com
Obsessive-compulsive disorder is a severe and disabling clinical condition that usually
arises in late adolescence or early adulthood and, if left untreated, has a chronic course …

Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice

JM Welch, J Lu, RM Rodriguiz, NC Trotta, J Peca… - Nature, 2007 - nature.com
Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by
persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction …

Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment

C Pittenger, MH Bloch, K Williams - Pharmacology & therapeutics, 2011 - Elsevier
Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …

Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept

CI Rodriguez, LS Kegeles, A Levinson… - …, 2013 - nature.com
Serotonin reuptake inhibitors (SRIs), the first-line pharmacological treatment for obsessive-
compulsive disorder (OCD), have two limitations: incomplete symptom relief and 2–3 months …

Genome-wide association study of obsessive-compulsive disorder

SE Stewart, D Yu, JM Scharf, BM Neale… - Molecular …, 2013 - nature.com
Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative …