COVID-19, loneliness, social isolation and risk of dementia in older people: a systematic review and meta-analysis of the relevant literature

C Lazzari, M Rabottini - … Journal of Psychiatry in Clinical Practice, 2022 - Taylor & Francis
Objectives During the COVID-19 lockdown, social isolation and feelings of loneliness (SIFL)
in the older population have increased, and they can be a risk of dementia, especially in …

Neurobiology of loneliness, isolation, and loss: integrating human and animal perspectives

EM Vitale, AS Smith - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
In social species such as humans, non-human primates, and even many rodent species,
social interaction and the maintenance of social bonds are necessary for mental and …

What's wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research

HM Butler-Struben, AC Kentner… - …, 2022 - nature.com
The field of neuropsychopharmacology relies on behavioral assays to quantify behavioral
processes related to mental illness and substance use disorders. Although these assays …

Pharmacological, neurochemical, and behavioral mechanisms underlying the anxiolytic-and antidepressant-like effects of flavonoid chrysin

JF Rodríguez-Landa, LJ German-Ponciano… - Molecules, 2022 - mdpi.com
Chrysin (5, 7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora
coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts …

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

H González-Pardo, JL Arias, G Vallejo, NM Conejo - PloS one, 2019 - journals.plos.org
Early life stress is associated with long-term and pervasive adverse effects on
neuroendocrine development, affecting normal cognitive and emotional development …

The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle

M Rojas‐Carvajal, A Sequeira‐Cordero… - European Journal of …, 2022 - Wiley Online Library
Mounting evidence shows that physical activity, social interaction and sensorimotor
stimulation provided by environmental enrichment (EE) exert several neurobehavioural …

Anxiety, depression, impulsivity, and mindfulness among higher education faculty during COVID-19

LL Weyandt, A Francis, E Shepard… - Health Behavior and …, 2020 - ingentaconnect.com
Objective: In this paper, we examine the relationships among symptoms of anxiety and
depression, impulsivity, and mindfulness among university faculty members during the …

Social isolation during COVID-19 pandemic. Perceived stress and containment measures compliance among Polish and Italian residents

J Grabowski, J Stepien, P Waszak, T Michalski… - Frontiers in …, 2021 - frontiersin.org
Background In this study, we analyze the association of social isolation in the first phase of
the pandemic with perceived stress among residents of Poland and Italy with a look at how …

HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

XY Sun, T Zheng, X Yang, L Liu, SS Gao, HB Xu… - Journal of …, 2019 - Springer
Background Inflammation can induce cognitive dysfunction in patients who undergo surgery.
Previous studies have demonstrated that both acute peripheral inflammation and …

Effects of social isolation on the development of anxiety and depression-like behavior in model experiments in animals

GA Grigoryan, IV Pavlova, MI Zaichenko - Neuroscience and behavioral …, 2022 - Springer
This review describes the role of social isolation in the development of anxiety and
depression-like behavior in rodents. The duration of social isolation, age from onset of social …