Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

The long QT syndrome (LQTS) is largely treated pharmacologically with β‐blockers, despite
the role of sympathetic activity in LQTS being poorly understood. Using the trigger–substrate …

Incidence of cardiac arrhythmias increases significantly with age. In order to effectively
stratify arrhythmic risk in the aging population it is crucial to elucidate the relevant underlying …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with mutations
in the cardiac ryanodine receptor (RyR2). These result in stress‐induced ventricular …

Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly
perturbs myocyte Ca2+ homeostasis, slows myocardial action potential conduction, and …

Bisphosphonates (BPs) are widely prescribed drugs used to treat osteoporosis, commonly
arising in postmenopausal women and in chronic glucocorticoid use. Their mechanism of …

Heart failure (HF) affects 23 million people worldwide and results in 300000 annual deaths.
It is associated with many comorbidities, such as obstructive sleep apnea (OSA), and risk …

Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by
prolongation of the action potential duration (APD) at the cellular level, is linked to increased …

Sympathetic nerve sprouting in healed myocardial infarction (MI) has been associated with
high incidences of lethal arrhythmias, but the underlying mechanisms are largely unknown …

Risk stratification in the context of sudden cardiac death has been acknowledged as one of
the major challenges facing cardiology for the past four decades. In recent years, the advent …