phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …

Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …

Background Though, first identified in the gastrointestinal tract, bitter taste receptors are now
believed to be ubiquitously expressed in several regions of the body, including the …

Gastric cancer (GC) remains a predominant form of malignant tumor globally, necessitating
innovative non-surgical therapeutic approaches. This investigation aimed to delineate the …

Background Classically activated M1 macrophages, characterized by aberrant glycolysis
and secretion of inflammatory cytokines, play pivotal roles in inflammatory diseases …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Neutrophil extracellular traps (NETs) emerge from the cell as a DNA scaffold associated with
cytoplasmic and granular proteins, able to immobilize and kill pathogens. This association …

ABSTRACT MARCKS is an actin and PIP2-binding protein that plays an essential role in
neutrophil migration and adhesion; however, the molecular details regarding MARCKS …

The intracellular distribution of phosphatase and tensin homolog (PTEN) is closely related to
directed cell migration. In single cells, PTEN accumulates at the rear of the cell before and …

Background Accumulating evidence suggests a regulatory role of Wnt proteins in innate
immune responses. However, the effects of Wnt3a signaling on TLR4-mediated …