Targeting the cancer epigenome for therapy

PA Jones, JPJ Issa, S Baylin - Nature Reviews Genetics, 2016 - nature.com
Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …

Deep learning in digital pathology image analysis: a survey

S Deng, X Zhang, W Yan, EIC Chang, Y Fan, M Lai… - Frontiers of …, 2020 - Springer
Deep learning (DL) has achieved state-of-the-art performance in many digital pathology
analysis tasks. Traditional methods usually require hand-crafted domain-specific features …

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

N Coudray, PS Ocampo, T Sakellaropoulos, N Narula… - Nature medicine, 2018 - nature.com
Visual inspection of histopathology slides is one of the main methods used by pathologists
to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and …

The prognostic value of PD-L1 expression for non-small cell lung cancer patients: a meta-analysis

A Wang, HY Wang, Y Liu, MC Zhao, HJ Zhang… - European Journal of …, 2015 - Elsevier
Background A meta-analysis was conducted to investigate the much-debated relationship
between the gene expression of programmed cell death-ligand 1 (PD-L1) and cancer …

Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance

S Maity, KSR Pai, Y Nayak - Pharmacological Reports, 2020 - Springer
Background The epidermal growth factor receptor (EGFR) inhibitors represent the first-line
therapy regimen for non-small cell lung cancer (NSCLC). Most of these inhibitors target the …

Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution

K Li, M Yang, N Liang, S Li - Oncology reports, 2017 - spandidos-publications.com
Mutations in epidermal growth factor receptor (EGFR) play critical roles in the pathogenesis
of non-small cell lung cancer (NSCLC), and they are highly associated with sensitivity to …

The anticancer effect of Huaier

X Song, Y Li, H Zhang, Q Yang - Oncology reports, 2015 - spandidos-publications.com
Abstract Trametes robiniophila Murr.(Huaier) is a sandy beige mushroom found on the
trunks of trees and has been widely used in traditional Chinese medicine (TCM) for~ 1,600 …

Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer

L Nibid, C Greco, E Cordelli, G Sabarese, M Fiore… - Plos one, 2023 - journals.plos.org
Despite the advantages offered by personalized treatments, there is presently no way to
predict response to chemoradiotherapy in patients with non-small cell lung cancer (NSCLC) …

Intratumor heterogeneity in early lung adenocarcinoma

MF Senosain, PP Massion - Frontiers in oncology, 2020 - frontiersin.org
Lung cancer is one of the deadliest diseases in the world and is the leading cause of cancer-
related deaths. Among the histological types, adenocarcinoma is the most common, and it is …

c-Met and other cell surface molecules: interaction, activation and functional consequences

G Viticchiè, PAJ Muller - Biomedicines, 2015 - mdpi.com
The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine
kinase receptors, yet its biological functions and activation mechanisms are still not fully …