[HTML][HTML] Targeted and cytotoxic inhibitors used in the treatment of breast cancer

R Roskoski Jr - Pharmacological Research, 2024 - Elsevier
Breast cancer is the most commonly diagnosed malignancy and the fifth leading cause of
cancer deaths worldwide. Surgery and radiation therapy are localized therapies for early …

[HTML][HTML] Cost in the United States of FDA-approved small molecule protein kinase inhibitors used in the treatment of neoplastic and non-neoplastic diseases

R Roskoski Jr - Pharmacological Research, 2024 - Elsevier
Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

[HTML][HTML] 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7)

F Cardoso, S Paluch-Shimon, E Schumacher-Wulf… - The breast, 2024 - Elsevier
This manuscript describes the Advanced Breast Cancer (ABC) international consensus
guidelines updated at the last two ABC international consensus conferences (ABC 6 in …

Revisiting ovarian function suppression with GnRH agonists for premenopausal women with breast cancer: Who should use and the impact on survival outcomes

L Ma, B Yang, J Wu - Cancer Treatment Reviews, 2024 - Elsevier
Breast cancer diagnosed in premenopausal women tends to be more aggressive and the
benefit of ovarian function suppression (OFS), at least in certain groups of patients, is well …

Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer

GS Sonke, A van Ommen-Nijhof, N Wortelboer… - Nature, 2024 - nature.com
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) in combination with endocrine therapy
improve the outcomes of patients with hormone-receptor (HR)-positive, HER2-negative …

Outcomes of breast cancer screening strategies based on cancer intervention and surveillance modeling network estimates

DL Monticciolo, RE Hendrick, MA Helvie - Radiology, 2024 - pubs.rsna.org
Background There is ongoing debate about recommendations for breast cancer screening
strategies, specifically regarding the frequency of screening and the age at which to initiate …

Evaluation of neoadjuvant chemotherapy for clinical T1 triple-negative breast cancer

Q Hao, L Dai, L Chang, D Song, D Liu, X Ma, H Wu… - Scientific reports, 2024 - nature.com
The role of neoadjuvant chemotherapy and its benefits in patients with triple-negative breast
cancer (TNBC) and small tumors are unclear. This study aims to compare survival …

Nodal burden and oncologic outcomes in patients with residual isolated tumor cells after neoadjuvant chemotherapy (ypN0i+): The OPBC-05/ICARO Study

G Montagna, A Laws, M Ferrucci, MM Mrdutt… - Journal of clinical …, 2024 - ascopubs.org
PURPOSE The nodal burden of patients with residual isolated tumor cells (ITCs) in the
sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC)(ypN0i+) is unknown …

Repurposing cardiac glycosides for anticancer treatment: a review of clinical studies

WNN Nabil, R Dai, M Liu, Z Xi, H Xu - Drug Discovery Today, 2024 - Elsevier
Cardiac glycosides (CGs), which are traditionally used for heart disease, show promise for
cancer therapy. However, there is a lack of a comprehensive review of clinical studies in this …

[HTML][HTML] An advanced machine learning model for a web-based artificial intelligence–based clinical decision support system application: Model development and …

TH Lin, HY Chung, MJ Jian, CK Chang… - Journal of Medical …, 2024 - jmir.org
Background Breast cancer is a leading global health concern, necessitating advancements
in recurrence prediction and management. The development of an artificial intelligence (AI) …