The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

A fundamental shift in neuroscience suggests bidirectional interaction of gut microbiota with
the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been …

The importance of tryptophan as a precursor for neuroactive compounds has long been
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …

Objective Disturbances in the kynurenine pathway have been implicated in the
pathophysiology of psychotic and mood disorders, as well as several other psychiatric …

Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder,
bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the …

Activation of the kynurenine pathway is one of the described mechanisms by which
inflammation can induce depression. It involves multiple pathways including interference …

Major depressive disorder (MDD) is a serious psychiatric disorder that in extreme cases can
lead to suicide. Evidence suggests that alterations in the kynurenine pathway (KP) …

Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …