Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Affibody molecules can be used as tools for molecular recognition in diagnostic and
therapeutic applications. There are several preclinical studies reported on diagnostic and …

The concept of engineering robust protein scaffolds for novel binding functions emerged 20
years ago, one decade after the advent of recombinant antibody technology. Early examples …

Proteolysis-targeting chimeras (PROTACs) are an emerging class of promising therapeutic
molecules that can target specific disease-related proteins and then degrade them by the …

The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

Small engineered scaffold proteins have attracted attention as probes for radionuclide-
based molecular imaging. One class of these imaging probes, termed ABD-Derived Affinity …

The human epidermal growth factor receptor family (EGFR-family, other designations: HER
family, RTK Class I) is strongly linked to oncogenic transformation. Its members are …

The human epidermal growth factor receptor 3 (HER3) is overexpressed in several cancers,
being linked to a more resistant phenotype and hence leading to poor patient prognosis …

Human epidermal growth factor receptor 3 (HER3) is involved in the progression of various
cancers and in resistance to therapies targeting the HER family. In vivo imaging of HER3 …

Photothermal therapy (PTT), mediated by tumor-targeted drug delivery of indocyanine green
(ICG), is a promising strategy for cancer therapy. Human epidermal growth factor receptor 3 …