Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases

H Han, G Zhang, X Zhang, Q Zhao - Inflammopharmacology, 2024 - Springer
Inflammatory diseases, including psoriasis, atherosclerosis, rheumatoid arthritis, and
ulcerative colitis, are characterized by persistent inflammation. Moreover, the existing …

Immunometabolism in atherosclerosis: a new understanding of an old disease

M Certo, M Rahimzadeh, C Mauro - Trends in Biochemical Sciences, 2024 - cell.com
Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death
globally, necessitating innovative approaches to target pro-atherogenic pathways. Recent …

Aconitate decarboxylase 1 (Acod1) suppresses inflammatory stimuli-induced immune responses in Japanese flounder (Paralichthys olivaceus)

S Li, Y Cao, X Cui, J Sun - Aquaculture, 2024 - Elsevier
Abstract Aconitate decarboxylase 1 (ACOD1, formerly termed as immunoresponsive gene 1)
is an enzyme responsible for generation of anti-inflammatory metabolite itaconate through …

Acod1 Mediate Anti-inflammatory Treg Function in Sepsis

ME Mickael, N Kubick, AG Atansov, JO Horbańczuk… - 2024 - preprints.org
Sepsis is a serious disease that can lead to mortality. The etiology of the disease is
connected to how the body as a host reacts toward microbes such as bacteria, viruses, and …

The emerging role of ACOD1/itaconate pathway in atherosclerosis

J Xu, S Xu - Trends in Molecular Medicine, 2024 - cell.com
As an endogenous immunometabolite, itaconate has excellent anti-inflammatory effects.
However, it remains unknown whether itaconate protects against atherosclerosis. Two …