Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Vascular contributions to Alzheimer's disease

LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives

S Lista, R González-Domínguez, S López-Ortiz… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …

Cerebral small vessel disease pathology in COVID-19 patients: A systematic review

CD Owens, CB Pinto, S Detwiler, P Mukli… - Ageing Research …, 2023 - Elsevier
Cerebral small vessel disease (CSVD) is the leading cause of vascular cognitive impairment
and is associated with COVID-19. However, contributing factors that often accompany CSVD …

Two decades of astrocytes in neurovascular coupling

A Lia, A Di Spiezio, M Speggiorin… - Frontiers in Network …, 2023 - frontiersin.org
The brain is a highly energy demanding organ, which accounts in humans for the 20% of
total energy consumption at resting state although comprising only 2% of the body mass …

Pericytes in Alzheimer's disease: Key players and therapeutic targets

Y Zhang, BR Mu, Z Ran, T Zhu, X Huang, X Yang… - Experimental …, 2024 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to
progressive cognitive decline and neuropathological changes. Pericytes, which are vessel …

Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke

J Fu, H Liang, P Yuan, Z Wei, P Zhong - Frontiers in Cellular …, 2023 - frontiersin.org
Pericytes play an indispensable role in various organs and biological processes, such as
promoting angiogenesis, regulating microvascular blood flow, and participating in immune …

Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms

AF Khan, Y Iturria-Medina - Translational Psychiatry, 2024 - nature.com
From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …

[HTML][HTML] Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer's disease: A narrative review

A Maggiore, V Latina, M D'Erme, G Amadoro… - Ageing Research …, 2024 - Elsevier
Alzheimer's Disease (AD) is the most common form of dementia among elderly people. This
disease imposes a significant burden on the healthcare system, society, and economy due …

Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations

S Nasim, C Bichsel, A Pinto, S Alexandrescu… - Angiogenesis, 2024 - Springer
Capillary malformations (CM) are congenital vascular irregularities of capillary and venous
blood vessels that appear in the skin, leptomeninges of the brain, and the choroid of the eye …