A review of pathway-based analysis tools that visualize genetic variants

E Cirillo, LD Parnell, CT Evelo - Frontiers in genetics, 2017 - frontiersin.org
Pathway analysis is a powerful method for data analysis in genomics, most often applied to
gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) …

Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells

N Provencal, MJ Suderman, C Guillemin, F Vitaro… - PloS one, 2014 - journals.plos.org
Background Chronic physical aggression (CPA) is characterized by frequent use of physical
aggression from early childhood to adolescence. Observed in approximately 5% of males …

Selective release of miRNAs via extracellular vesicles is associated with house‐dust mite allergen‐induced airway inflammation

Y Gon, S Maruoka, T Inoue, K Kuroda… - Clinical & …, 2017 - Wiley Online Library
Background MicroRNAs (miRNAs) may facilitate cell‐to‐cell communication via extracellular
vesicles (EVs). The biological roles of miRNAs in EVs on allergic airway inflammation are …

Systems biology approaches to finding novel pain mediators

A Antunes‐Martins, JR Perkins, J Lees… - … Systems Biology and …, 2013 - Wiley Online Library
Chronic pain represents a major health burden; this maladaptive pain state occurs as a
consequence of hypersensitivity within the peripheral and central components of the …

Unraveling the molecular signature of extracellular vesicles from endometrial-derived mesenchymal stem cells: potential modulatory effects and therapeutic …

F Marinaro, M Gómez-Serrano, I Jorge… - … in bioengineering and …, 2019 - frontiersin.org
Endometrial-derived Mesenchymal Stem Cells (endMSCs) are involved in the regeneration
and remodeling of human endometrium, being considered one of the most promising …

Treatment with suboptimal dose of benznidazole mitigates immune response molecular pathways in mice with chronic chagas cardiomyopathy

PSG Farani, K Begum, G Vilar-Pereira… - Frontiers in Cellular …, 2021 - frontiersin.org
Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe form of Chagas
disease, a neglected tropical illness caused by the protozoan Trypanosoma cruzi, and the …

Pathway-based approach using hierarchical components of collapsed rare variants

S Lee, S Choi, YJ Kim, BJ Kim… - …, 2016 - academic.oup.com
Motivation To address 'missing heritability'issue, many statistical methods for pathway-based
analyses using rare variants have been proposed to analyze pathways individually …

Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions

A Rashid, C Zeng, G Motta-Ribeiro, ST Dillon… - Scientific Reports, 2022 - nature.com
Atelectasis is a frequent clinical condition, yet knowledge is limited and controversial on its
biological contribution towards lung injury. We assessed the regional proteomics of …

Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone

T Liu, NM Gatto, Z Chen, H Qiu, G Lee… - Precision clinical …, 2020 - academic.oup.com
A long-term vegetarian diet plays a role in the longevity and maintenance of the healthspan,
but the underlying mechanisms for these observations are largely unknown. Particularly, it is …

Novel Genes Associated With Atrial Fibrillation and the Predictive Models for AF Incorporating Polygenic Risk Score and PheWAS-Derived Risk Factors

SY Chen, YC Chen, TY Liu, KC Chang… - Canadian Journal of …, 2024 - Elsevier
Background Atrial fibrillation (AF), the most common atrial arrhythmia, presents with varied
clinical manifestations. Despite the identification of genetic loci associated with AF …