Diverse forms of resistance to anticancer drugs can lead to the failure of chemotherapy.
Drug resistance is one of the most intractable issues for successfully treating cancer in …

One of the most important resources for researchers of noncoding RNAs is the information
available in public databases spread over the internet. However, the effective exploration of …

Drug resistance poses a significant challenge in cancer treatment. Despite the initial
effectiveness of therapies such as chemotherapy, targeted therapy and immunotherapy …

Drug response to many diseases varies dramatically due to the complex genomics and
functional features and contexts. Cellular diversity of human tissues, especially tumors, is …

Drug sensitivity has always been at the core of individualized cancer chemotherapy.
However, we have been overwhelmed by large-scale pharmacogenomic data in the era of …

Chemoresistance remains the major challenge for successful treatment of acute myeloid
leukemia (AML). Although recent mouse studies suggest that treatment response of …

Non-small cell lung cancer with an activating epidermal growth factor receptor (EGFR)
mutation responds well to targeted drugs. In most cases, drug resistance appears after about …

The treatment failure rates of acute leukemia with rearrangements of the Mixed Lineage
Leukemia (MLL) gene highlight the need for novel therapeutic approaches. Taking into …

Exploring the rewiring pattern of gene regulatory networks between different pathological
states is an important task in bioinformatics. Although a number of computational …

Background Individualized drug response prediction is vital for achieving personalized
treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles …