The unnecessary use of antibiotics and concomitant rapid growth of antibiotic resistance
(ABR) is a widely acknowledged threat to global health, development, and sustainability …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

The rapid emergence and dissemination of antibiotic-resistant microorganisms in ICUs
worldwide threaten adequate antibiotic coverage of infected patients in this environment …

Background Bloodstream infections remain one of the major challenges in intensive care
units, leading to sepsis or even septic shock in many cases. Due to the lack of timely …

The Clinical Challenge of Sepsis Identification and Monitoring | PLOS Medicine Skip to main
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Over half of the nearly two million healthcare-associated infections can be attributed to
indwelling medical devices. In this review, we highlight the difficulty in diagnosing …

The microbiological management of patients with suspected bacterial infection includes the
identification of the pathogen and the determination of the antibiotic susceptibility. These …