Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Besides organic compounds such as lactose and proteins, cheese whey is rich in other
nutrients. Damping of these valuable compounds to the environment, first, harms the …

Abstract The Major Facilitator Superfamily (MFS) is currently the largest characterized
superfamily of transmembrane secondary transport proteins. Its diverse members are found …

Members of the Zrt and Irt protein (ZIP) family are a central participant in transition metal
homeostasis as they function to increase the cytosolic concentration of zinc and/or iron …

Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic
relationships and characterizing families and superfamilies of transport proteins. Results …

The Major Facilitator Superfamily (MFS) is one of the largest classes of secondary active
transporters and is widely expressed in many domains of life. It is characterized by a …

Transmembrane proteins perform a variety of important biological functions necessary for
the survival and growth of the cells. Membrane proteins are built up by transmembrane …

MarR-family transcription factors often control antioxidant enzymes, multidrug efflux pumps
or virulence factors in bacterial pathogens and confer resistance towards oxidative stress …

Domain classifications are a useful resource for computational analysis of the protein
structure, but elements of their composition are often opaque to potential users. We perform …

The major facilitator superfamily (MFS) is a diverse group of secondary transporters with
members found in all kingdoms of life. A paradigm for MFS is the lactose permease (LacY) of …