Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

When cells are observed by phase contrast microscopy, nucleoli are among the most
conspicuous structures. The nucleolus was formally described between 1835 and 1839, but …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional
ribosome formation, composed of∼ 70 assembly factors and several small nucleolar RNAs …

Alzheimer's disease (AD) is a progressive and devastating disorder that is often preceded by
mild cognitive impairment (MCI). In the present study, we report that in multiple cortical areas …

Cancer cells must integrate multiple biosynthetic demands to drive indefinite proliferation.
How these key cellular processes, such as metabolism and protein synthesis, crosstalk to …

Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at
advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with …

Mutations that directly affect transcription by RNA polymerases rank among the most central
mediators of malignant transformation, but the frequency of new anticancer drugs that …

Background The nucleolus is a subnuclear organelle in which rRNAs are transcribed,
processed, and assembled with ribosomal proteins into ribosome subunits. Mass …

Understanding the regulation and structure of ribosomes is essential to understanding
protein synthesis and its dysregulation in disease. While ribosomes are believed to have a …