Increasingly vitamin D deficiency is being associated with a number of psychiatric
conditions. In particular for disorders with a developmental basis, such as autistic spectrum …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

In Parkinson disease (PD), affected midbrain dopamine (DA) neurons lose specific
dopaminergic properties before the neurons die. How the phenotype of DA neurons is …

It has been 20 years since we first proposed vitamin D as a “possible” neurosteroid.(1) Our
work over the last two decades, particularly results from our cellular and animal models, has …

Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical
in the development and maintenance of the dopaminergic system and as such it may have …

Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control
of voluntary movement and the regulation of emotion, and are severely affected in …

Several studies have demonstrated that intrastriatal injections of fibrillar α-synuclein in
rodent brain induced a Parkinson's disease-like propagation of Lewy body pathology with …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

The specification of neurotransmitter phenotype is an important aspect of neuronal fate
determination. Substantial progress has been made in uncovering key extracellular signals …

The past two decades have seen an explosion in our understanding of the origin and
development of the midbrain dopamine system. Much of this work has been focused on the …