The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

▪ Abstract Early development of the vertebrate skeleton depends on genes that pattern the
distribution and proliferation of cells from cranial neural crest, sclerotomes, and lateral plate …

The Notch gene family encodes large transmembrane receptors that are components of an
evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 …

Drosophila melanogaster is emerging as one of the most effective tools for analyzing the
function of human disease genes, including those responsible for developmental and …

The Notch signaling pathway is an evolutionarily conserved intercellular signaling
mechanism essential for embryonic development in mammals. Mutations in the human …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

We report the cloning and characterization of a new member of the Delta family of Notch
ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a …