Opioids still appear to be most promising among current approaches in the development of
analgesics. Basic knowledge about pathophysiology of clinical pain and novel insights in …

Spinal cord injury (SCI) is a devastating injury to the central nervous system in which 60 to
80% of patients experience chronic pain. Unfortunately, this pain is notoriously difficult to …

Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects
and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for …

Opioids are employed in the management of chemotherapy-induced neuropathic pain
(CINP) when other pain management approaches have failed and proven ineffective …

Neuropathic pain (NP) results from injury to or disease of the somatosensory system. It is
estimated that approximately 7% to 10% of the population and 25% to 30% of individuals …

Paclitaxel, a frequently utilized chemotherapeutic agent, often gives rise to severe and
distressing sensory neuropathy in patients undergoing chemotherapy. Unfortunately, current …

Microglia can modulate spinal nociceptive transmission. Yet, their role in spinal cord
stimulation (SCS)-induced pain inhibition is unclear. Here, we examined how SCS affects …

Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment,
particularly by opioids. After SCI, DRG neurons show hyperactivity and chronic …

Pain sensitization in spinal cord injury (SCI)-induced central neuropathic pain has been a
research target. Additionally, suberoylanilide hydroxamic acid (SAHA) has been reported to …

Chronic pain is a common medical complication experienced by those living with spinal cord
injury (SCI) and leads to worsened quality of life. The pathophysiology of SCI pain is poorly …