PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Using the intranasal route to administer drugs to treat neurological and psychiatric illnesses: rationale, successes, and future needs

A Lofts, F Abu-Hijleh, N Rigg, RK Mishra, T Hoare - CNS drugs, 2022 - Springer
While the intranasal administration of drugs to the brain has been gaining both research
attention and regulatory success over the past several years, key fundamental and …

Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease

R Taliyan, V Kakoty, KC Sarathlal… - Journal of Controlled …, 2022 - Elsevier
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …

Simultaneous intranasal codelivery of donepezil and memantine in a nanocolloidal carrier: optimization, pharmacokinetics, and pharmacodynamics studies

M Handa, SN Sanap, RS Bhatta, GP Patil… - Molecular …, 2023 - ACS Publications
This work focuses on developing nanoemulsions using a low-energy emulsification method
for the codelivery of donepezil and memantine in one dosage form intended to be …

[HTML][HTML] Recent nanoengineered diagnostic and therapeutic advancements in management of Sepsis

M Soni, M Handa, KK Singh, R Shukla - Journal of Controlled Release, 2022 - Elsevier
COVID-19 acquired symptoms have affected the worldwide population and increased the
load of Intensive care unit (ICU) patient admissions. A large number of patients admitted to …

Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting

M Handa, S Beg, R Shukla, MA Barkat… - Journal of Controlled …, 2021 - Elsevier
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current treatments available for variety of cancers is considered to be suboptimal …

Drug discovery and development targeting dementia

A Zagórska, A Czopek, M Fryc, A Jaromin, BJ Boyd - Pharmaceuticals, 2023 - mdpi.com
Dementia, most often associated with neurodegenerative diseases, affects millions of
people worldwide, predominantly the elderly. Unfortunately, no treatment is still available …

Upgrading the transdermal biomedical capabilities of thyme essential oil nanoemulsions using amphiphilic oligochitosan vehicles

AM Nasr, YI Mortagi, NHA Elwahab, MY Alfaifi… - Pharmaceutics, 2022 - mdpi.com
(1) Background: Thymus vulgaris L.(thyme) essential oil (TEO) has gained much attention
because of its long history of medicinal usage. However, the lack of precise chemical …

Study of nanoemulsions using carvacrol/MCT-(Oleic acid-potassium oleate)/Tween 80®-water system by low energy method

E Santamaría, A Maestro, S Vilchez, C González - Heliyon, 2023 - cell.com
Carvacrol is studied in different fields due to its microbial and antioxidant properties. Its use
is limited because of the water insolubility and its strong taste. To overcome these problems …

Nano and microemulsions for the treatment of depressive and anxiety disorders: An efficient approach to improve solubility, brain bioavailability and therapeutic …

PC Pires, AC Paiva-Santos, F Veiga - Pharmaceutics, 2022 - mdpi.com
Most drugs used for the treatment of depression, anxiety and related disorders have low
absorption, high metabolism, low brain targeting and/or low water solubility, which can make …