Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …

Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell
with the necessary energy and cofactors to promote cell survival and proliferation. A …

Access to efficient enzymatic channeling is desired for improving all manner of designer
biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self …

Metabolites are the end products of cellular regulatory processes, and their levels can be
regarded as the ultimate response of biological systems to genetic or environmental …

Now that complete genome sequences are available for a variety of organisms, the
elucidation of gene functions involved in metabolism necessarily includes a better …

Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also
occur in Alzheimer's disease (AD). The degree of clinical disability in AD correlates closely …

MAP kinases help to mediate diverse processes ranging from transcription of
protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase …

Metabolons are transient multi-protein complexes of sequential enzymes that mediate
substrate channeling. They differ from multi-enzyme complexes in that they are dynamic …

Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential
substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in …

Mitochondria exert an immense amount of cytophysiological functions, but the structural
basis of most of these processes is still poorly understood. Here we use cross-linking mass …