Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Background: Antimicrobial resistance is a serious public-health problem throughout the
world. Escherichia coli, the most common Gram-negative microorganism, has developed …

Background Infections caused by KPC-producing Klebsiella pneumoniae (Kp) are
associated with high mortality. Therefore, new treatment options are urgently required …

Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) is one of the
most commonly found nosocomial infections in critically ill patients. However, the …

Introduction Antimicrobial treatments for carbapenem-resistant Enterobacteriaceae (CRE)
bacteremia are limited, with colistin-based regimens being a primary therapy. Ceftazidime …

Background We evaluated the association between mortality and colistin resistance in
Acinetobacter baumannii infections and the interaction with antibiotic therapy. Methods This …

Objectives In vitro models showing synergism between polymyxins and carbapenems
support combination treatment for carbapenem-resistant Gram-negative (CRGN) infections …

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely
used in animal husbandry, plant cultivation, animal and human medicine and is increasingly …

Colistin resistance in Gram negative bacteria is mainly attributed to chromosomal mutations
in Two Component Systems (TCS) PhoPQ and PmrAB and plasmid-borne genes (mcr and …

Colistin provides in vitro activity against numerous ESBL-producing and carbapenem-
resistant bacteria. However, clinical information with respect to its utilization in infection …