Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

D Knights, KG Lassen, RJ Xavier - Gut, 2013 - gut.bmj.com
Studies of the genetics underlying inflammatory bowel diseases have increased our
understanding of the pathways involved in both ulcerative colitis and Crohn's disease and …

Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation

T Chiba, H Marusawa, T Ushijima - Gastroenterology, 2012 - Elsevier
Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …

[HTML][HTML] Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease

XR Xu, CQ Liu, BS Feng, ZJ Liu - World journal of gastroenterology …, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. The exact
etiology and pathology of IBD remain unknown. Available evidence suggests that an …

The emerging role of lncRNAs in inflammatory bowel disease

R Yarani, AH Mirza, S Kaur, F Pociot - Experimental & molecular …, 2018 - nature.com
Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development of
various diseases. Recently, an emerging body of evidence has indicated that lncRNAs play …

The worst things in life are free: the role of free heme in sickle cell disease

OT Gbotosho, MG Kapetanaki, GJ Kato - Frontiers in immunology, 2021 - frontiersin.org
Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Circulating MicroRNA in inflammatory bowel disease

A Paraskevi, G Theodoropoulos… - Journal of Crohn's …, 2012 - academic.oup.com
Background: MicroRNAs (miRNAs) consist of a group of small noncoding RNAs that partially
regulate gene expression. We investigated the expression patterns of commonly …

Mechanisms of initiation and progression of intestinal fibrosis in IBD

G Latella, J Di Gregorio, V Flati, F Rieder… - Scandinavian journal …, 2015 - Taylor & Francis
Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs). It
becomes clinically apparent in> 30% of patients with Crohn's disease (CD) and in about 5 …

Transcriptomic landscape of lncRNAs in inflammatory bowel disease

AH Mirza, CHB Berthelsen, SE Seemann, X Pan… - Genome medicine, 2015 - Springer
Background Inflammatory bowel disease (IBD) is a complex multi-factorial inflammatory
disease with Crohn's disease (CD) and ulcerative colitis (UC) being the two most common …

miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD

C He, Y Shi, R Wu, M Sun, L Fang, W Wu, C Liu… - Gut, 2016 - gut.bmj.com
Objective MicroRNA (miR)-301a is known to be involved in the tumourigenesis and
pathogenesis of several autoimmune diseases, but it remains unclear whether miR-301a is …

miRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease

S Dhuppar, G Murugaiyan - Trends in immunology, 2022 - cell.com
Inflammatory bowel disease (IBD) spans a range of chronic conditions affecting the
gastrointestinal (GI) tract, which are marked by intermittent flare-ups and remissions. IBD …