Neutrophil extracellular traps (NETs) arise from the release of granular and nuclear contents
of neutrophils in the extracellular space in response to different classes of microorganisms …

Pneumonia is a leading cause of death from infection in the United States and across the
globe. During pulmonary infection, clear resolution of host inflammatory responses occurs in …

Cytokine-based diagnostic assays are increasingly used in research and clinical practice.
Assays developed for adults such as the interferon-gamma release assay for tuberculosis …

Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which
leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune …

Background The inflammatory response to community‐acquired pneumonia (CAP) is
orchestrated through activation of cytokine networks and the complement system. We …

Abstract Class IIa histone deacetylases (Class IIa HDACs) play critical roles in regulating
essential cellular metabolism and inflammatory pathways. However, dissecting the specific …

Objectives We aimed to investigate the association between the time to positivity of blood
culture (TTP) with clinical outcome and severity of pneumococcal bacteremic pneumonia …

(1) Background: Sepsis is present in nearly 90% of critically ill patients with community-
acquired pneumonia (CAP). This systematic review updates the information on studies that …

The Clinical Presentation and Immunology of Viral Pneumonia... : Critical Care Explorations The
Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of …

HIV and pneumonia infections have both been shown to negatively impact lung function.
However, evidence of the role of inflammation on lung dysfunction in HIV and pneumonia co …