[HTML][HTML] Single-chain polymer nanoparticles in biomedical applications

NM Hamelmann, JMJ Paulusse - Journal of Controlled Release, 2023 - Elsevier
Single-chain polymer nanoparticles (SCNPs) are a well-defined and uniquely sized class of
polymer nanoparticles. The advances in polymer science over the past decades have …

Macromolecular superstructures: a future beyond single chain nanoparticles

H Frisch, BT Tuten… - Israel Journal of …, 2020 - Wiley Online Library
Over the last 100 years polymer chemistry has flourished in all areas and enabled control
over synthetic polymer architectures–including chain lengths, dispersity and monomer …

Visible‐Light‐Reactive Single‐Chain Nanoparticles

K Mundsinger, BT Tuten, L Wang… - Angewandte Chemie …, 2023 - Wiley Online Library
We introduce a single‐chain nanoparticle (SCNP) system capable of catalyzing the
photooxidation of nonpolar alkenes up to three times more efficiently than an equivalent …

100th Anniversary of macromolecular science viewpoint: re-examining single-chain nanoparticles

R Chen, EB Berda - ACS Macro Letters, 2020 - ACS Publications
Single-chain nanoparticles (SCNP) are a class of polymeric nanoparticles obtained from the
intramolecular cross-linking of polymers bearing reactive pendant groups. The development …

Photochemistry in confined environments for single-chain nanoparticle design

H Frisch, JP Menzel, FR Bloesser… - Journal of the …, 2018 - ACS Publications
Emulating nature's protein paradigm, single-chain nanoparticles (SCNP) are an emerging
class of nanomaterials. Synthetic access to SCNPs is limited by ultralow concentrations …

Supramolecular single-chain polymeric nanoparticles

GM ter Huurne, ARA Palmans, EW Meijer - CCS Chemistry, 2019 - chinesechemsoc.org
Nature has unparalleled control over the conformation and dynamics of its folded
macromolecular structures. Nature's ability to arrange amino acids into a precise spatial …

[HTML][HTML] Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging

APP Kröger, JMJ Paulusse - Journal of controlled release, 2018 - Elsevier
As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just
entered the field of (biomedical) applications, with recent advances in polymer science …

Control and characterization of the compactness of single-chain nanoparticles

S Liao, L Wei, LA Abriata, F Stellacci - Macromolecules, 2021 - ACS Publications
Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to
folded proteins; yet proteins have clear energy landscapes that determine precisely folded …

Confinement of folding motifs within central blocks improves single chain polymer nanoparticle folding

S Farazi, MH Stenzel, R Chapman - Polymer Chemistry, 2024 - pubs.rsc.org
Folding polymers into well-defined structures in solution is a critical step towards fully
synthetic protein mimics. Peptide motifs such as diphenylalanine (FF) provide a versatile …

An in-depth analysis approach enabling precision single chain nanoparticle design

J Engelke, BT Tuten, R Schweins, H Komber… - Polymer …, 2020 - pubs.rsc.org
The synthesis of single chain nanoparticles (SCNPs) is a vibrant field in macromolecular
science, enabled by a rich variety of synthetic strategies to induce macromolecular chain …