Mammalian aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that
belongs to the basic helix–loop–helix (bHLH)–PAS family of transcription factors, which are …

The intestinal homeostasis is an orchestrated dynamic equilibrium state composed of the
coexistence and interactions among the nutrients, microbial flora, and immune system. The …

Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

The epithelium and immune compartment in the intestine are constantly exposed to a
fluctuating external environment. Defective communication between these compartments at …

The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

Tryptophan is an essential amino acid, going through three different metabolic pathways in
the intestines. Indole pathway in the gut microbiota, serotonin system in the enterochromaffin …

Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide.
The etiology and pathogenesis of CRC remain unclear. A growing body of evidence …

The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and
mediates the toxic effects induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and …

The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many
important questions about its role in normal physiology and development. Moreover, we still …

All phases of carcinogenesis are affected by inflammation. Activation of the inflammasome is
a crucial signaling mechanism that leads to acute and chronic inflammation. When specific …