Therapeutic potential of foldamers: from chemical biology tools to drug candidates?
Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
Harnessing ligand design to develop primary and self-calibrated luminescent thermometers with field-induced single ion magnet behaviour in Dy 3+ complexes
J Corredoira-Vázquez, C González-Barreira… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Novel complexes {[Dy (LN6en)(OAc) 2](NO3)}· 2H2O (1· 2H2O) and {[Dy (LN6prop)(OAc)
2](NO3)}· CHCl3 (2· CHCl3), containing partially flexible symmetric N6 macrocycles, are …
2](NO3)}· CHCl3 (2· CHCl3), containing partially flexible symmetric N6 macrocycles, are …
Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery
Z Dongrui, M Miyamoto, H Yokoo… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Peptide foldamers play a critical role in pharmaceutical research and
biomedical applications. This review highlights recent (post-2020) advancements in novel …
biomedical applications. This review highlights recent (post-2020) advancements in novel …
Atomic-level engineering and imaging of polypeptoid crystal lattices
Rational design of supramolecular nanomaterials fundamentally depends upon an atomic-
level understanding of their structure and how it responds to chemical modifications. Here …
level understanding of their structure and how it responds to chemical modifications. Here …
A γ-amino acid that favors 12/10-helical secondary structure in α/γ-peptides
MW Giuliano, SJ Maynard, AM Almeida… - Journal of the …, 2014 - ACS Publications
H-bonded helices in conventional peptides (containing exclusively homochiral α-amino acid
residues) feature a uniform H-bonding directionality, N-terminal side C O to C-terminal side …
residues) feature a uniform H-bonding directionality, N-terminal side C O to C-terminal side …
Racemic DNA crystallography
Racemates increase the chances of crystallization by allowing molecular contacts to be
formed in a greater number of ways. With the advent of protein synthesis, the production of …
formed in a greater number of ways. With the advent of protein synthesis, the production of …
Heterogeneous H-bonding in a foldamer helix
Structural characterization of new α/γ-peptide foldamers containing the cyclically
constrained γ-amino acid I is described. Crystallographic and 2D NMR analysis shows that γ …
constrained γ-amino acid I is described. Crystallographic and 2D NMR analysis shows that γ …
Crystal structure of a complex between β-glucopyranose and a macrocyclic receptor with dendritic multicharged water solubilizing chains
PK Mandal, B Kauffmann, H Destecroix… - Chemical …, 2016 - pubs.rsc.org
Using commercial screens for crystallization of biomolecules and taking advantage of the
use of racemic crystallography allowed the production of X-ray quality single crystals and the …
use of racemic crystallography allowed the production of X-ray quality single crystals and the …
Carboxylated glucuronic poly-amido-saccharides as protein stabilizing agents
SE Stidham, SL Chin, EL Dane… - Journal of the American …, 2014 - ACS Publications
The synthesis of novel carbohydrate-based polymers allows the structure to be tailored at
the monomer level for a specific property and expands the range of available structures …
the monomer level for a specific property and expands the range of available structures …
12/10-helical β-peptide with dynamic folding propensity: coexistence of right-and left-handed helices in an enantiomeric foldamer
We present the first examples of atomic-resolution crystal data for the β-peptide 12/10-helix
from oligomers of cis-2-aminocyclohexane carboxylic acid (cis-ACHC) with alternating …
from oligomers of cis-2-aminocyclohexane carboxylic acid (cis-ACHC) with alternating …