Correlating enzymatic reactivity for different substrates using transferable data-driven collective variables
Machine learning (ML) is transforming the investigation of complex biological processes. In
enzymatic catalysis, one significant challenge is identifying the reactive conformations (RC) …
enzymatic catalysis, one significant challenge is identifying the reactive conformations (RC) …
How and when does an enzyme react? Unraveling α-Amylase catalytic activity with enhanced sampling techniques
Enzymatic catalysis is a complex process that can involve multiple conformations of the
enzyme: substrate complex and several competitive reaction pathways, resulting in a multi …
enzyme: substrate complex and several competitive reaction pathways, resulting in a multi …
Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles
AM Richard, NR Wong, K Harris, R Sundar… - Communications …, 2023 - nature.com
Alkyl isonitriles, R—NC, have previously been shown to ligate the heme (haem) iron of
cytochromes P450 in both accessible oxidation states (ferrous, Fe2+, and ferric, Fe3+) …
cytochromes P450 in both accessible oxidation states (ferrous, Fe2+, and ferric, Fe3+) …
Tracking protein–protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b 5
AM Richard, DF Estrada, L Flynn… - Physical Chemistry …, 2024 - pubs.rsc.org
The human steroidogenic cytochrome P450 CYP17A1 catalyzes two types of reactions in
the biosynthetic pathway leading from pregnenolone to testosterone and several other …
the biosynthetic pathway leading from pregnenolone to testosterone and several other …
[引用][C] 22nd International Conference on Cytochrome P450 (ICCP450).
JC Hackett - Journal of Inorganic Biochemistry, 2023 - europepmc.org
22nd International Conference on Cytochrome P450 (ICCP450). - Abstract - Europe PMC
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