Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are
defined by their highly conserved ETS DNA binding domain and predominant epithelial …

Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …

Background & Aims B cells infiltrate tumors, but little is known about how they affect tumor
growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16 …

Though invasive mucinous adenocarcinoma of the lung (IMA) is pathologically distinctive,
the molecular mechanism driving IMA is not well understood, which hampers efforts to …

SAM-pointed domain-containing ETS transcription factor (SPDEF) is expressed in normal
prostate epithelium. While its expression changes during prostate carcinogenesis (PCa), the …

Background & Aims The transcription factor atonal homolog 1 (ATOH1) controls the fate of
intestinal progenitors downstream of the Notch signaling pathway. Intestinal progenitors that …

SAM pointed domain containing E26 transformation-specific transcription factor (SPDEF)
plays dual roles in the initiation and development of human malignancies. However, the …

Abstract microRNA-485-5p (miR-485-5p) has been shown to act as a tumor-suppressor
gene in some cancers, such as ovarian epithelial tumors and oral tongue squamous cell …

Abstract Triple-Negative Breast Cancer is the most aggressive form and accounts the 15%−
25% of all breast cancer. Receptors are absent in triple-negative breast cancer, which …