Macrophages stand in the first line of defense against a variety of pathogens but are also
involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages …

Tumor necrosis factor alpha (TNF)-dependent modulation of immune responses and cell
death processes has long been the subject of intense research. Yet, its role in cancer …

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …

The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

Apoptosis by Death Factor: Cell Skip to Main Content Advertisement Cell This journal offers
authors two options (open access or subscription) to publish research Submit Log in Register …

APO‐1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces
apoptosis upon receptor oligomerization. In a search to identify intracellular signaling …